10 Best Bed Bug Sprays 2025 in the United States

The Ortho Home Defense Max Bed Bug, Flea and Tick Killer is a versatile 1-gallon spray designed to tackle bed bugs, including their eggs, as well as fleas and ticks. One of its strong points is its effectiveness against even the toughest bed bugs, including those resistant to common treatments. The Comfort Wand that comes with it makes it easier to apply, especially in hard-to-reach places such as mattress seams and baseboards. This feature can be a significant advantage for those dealing with infestations in multiple areas of their home.

Safety-wise, it should be used with care, keeping in mind the advice to use it as a spot treatment. It’s also important to note that while it is effective, it forms only one part of a three-step treatment system recommended by Ortho, which may require additional purchases for the best results. Users have generally rated it positively, with a 4.4 out of 5-star rating from nearly 29,000 reviews, indicating a high level of customer satisfaction. However, some users might find the scent unpleasant as it is noted to have a tick scent.

In terms of convenience, the product’s large volume (1 gallon) means you’ll have plenty of spray to cover a significant area, but it also makes the container heavier and potentially more cumbersome to handle. This product is well-suited for those looking for a comprehensive, albeit multi-step, solution to bed bug and flea infestations in their home.

The Eco Defense Bed Bug Killer is a natural bed bug and dust mite spray intended to kill bed bugs at all life stages on contact. One of its major strengths is its use of natural and plant-based ingredients, such as Sodium Lauryl Sulfate and Geranium Oil, making it a safer option for households concerned about harmful chemicals. This can be especially beneficial for families with young children or pets. The non-staining formula allows users to apply it directly onto sheets and mattresses without worrying about damage, adding convenience and reassurance.

Additionally, it's marketed as being fast-acting and easy to use, potentially making it a more efficient alternative to powders, traps, and foggers. However, there are a few potential drawbacks. While the product claims to be effective, the use of natural ingredients might not be as potent as chemical-based alternatives, which could require more frequent applications for severe infestations. In terms of odor, while the natural ingredients likely result in a less harsh smell compared to chemical sprays, some users might still find the scent of geranium oil to be strong.

The Eco Defense Bed Bug Killer appears to be a good option for those looking for a safer and non-toxic way to combat bed bugs, though it might not be the most heavy-duty solution for severe infestations.

The Hot Shot Ready-to-Use Bed Bug Killer Spray is a versatile option designed to tackle bed bugs, bed bug eggs, fleas, and dust mites. Its water-based formula is beneficial as it is non-staining and leaves no odor, making it more pleasant for indoor use without worrying about lingering smells or marks. This spray is easy to use for spot treatments on mattresses, ensuring that all crucial areas are covered without the need for extensive spraying, although it should not be used on pets.

The 32-ounce volume provides ample product for multiple applications, which is necessary since the instructions recommend reapplication every two weeks as part of a comprehensive treatment plan. Users need to be diligent with this reapplication schedule to maintain control over an infestation, which could be seen as a drawback for those looking for a one-time solution.

Despite this, its targeted spray form and odorless nature make it a user-friendly option for those dealing with bed bugs and related pests inside the home. It is particularly effective when used as part of a broader pest control strategy.