10 Best Spider Killers 2025 in the United States

The Ortho Home Defense Insect Killer for Indoor & Perimeter Refill2 is a versatile choice for managing not just spiders but also a range of other insects like ants, roaches, and fleas. This makes it a handy all-in-one solution for households dealing with multiple types of pests. One of its major strengths is its longevity, providing up to 12 months of protection indoors on non-porous surfaces, which means less frequent reapplication is needed.

This product is easy to use, particularly if you have the Comfort Wand from the original container, allowing for precise application in both indoor and outdoor settings like kitchens, bathrooms, and around the house perimeter. It is unscented, which is a plus for those sensitive to strong chemical smells. However, the product's safety profile is crucial to consider, especially around pets and children. While it is effective, it's important to follow the usage instructions carefully to avoid any potential harm.

The environmental impact is another aspect to note; chemical insecticides can have broader ecological effects, so this product might not be the best choice for those seeking an eco-friendly option. The 1-gallon size can be cumbersome to handle, and although it covers a good area, those with extensive pest problems might find it insufficient for larger properties. This insect killer is highly effective and user-friendly for those needing comprehensive pest control, but safety and environmental concerns should be weighed before use.

Miss Muffet's Revenge by Wet & Forget is a spider killer designed for both indoor and outdoor use. It features Bifenthrin as the active ingredient, which is effective against most spiders except Black Widow and Brown Recluse. One of its strongest points is its long-lasting residual effect, providing protection for up to 12 months with a single application. The attached sprayer is convenient, allowing you to spray up to 10 feet, which is great for those hard-to-reach areas.

Users have found it easy to apply, with the recommendation to use it in calm weather and allow it to dry completely for the best results. However, safety precautions should be taken to avoid entering treated areas before the spray is dry. The product has an unlimited shelf life and is ready to use straight out of the package, which adds to its convenience. On the downside, it is not suitable for eliminating Black Widow and Brown Recluse spiders, which could be a significant limitation for some users. Additionally, while it is effective, Bifenthrin is a chemical insecticide, which may raise environmental concerns for those looking for eco-friendly options.

If you need a reliable solution for most spider issues and ease of use is a priority, this product is a strong candidate.

The Spectracide Bug Stop Home Barrier is a versatile product designed for indoor and outdoor use, specifically targeting insects like spiders, ants, and roaches. One of its main strengths is its ability to kill spiders and other pests on contact, providing up to 12 months of control for cockroaches on non-porous surfaces. The active ingredient, Gamma-Cyhalothrin, is effective in tackling various pests, making it a comprehensive solution for household insect control.

The water-based, clear formula is non-staining and leaves no odor or oily residue, making it suitable for use in different areas of your home without causing damage or lingering smells. Its ready-to-use form eliminates the need for mixing, adding to its convenience and ease of use. Safety-wise, it is essential to handle with care due to the chemical content. Users should follow the instructions for safe application, especially around children and pets.

In terms of environmental impact, it is not the most eco-friendly option due to the synthetic chemical ingredients. However, for those prioritizing immediate and extended pest control, it serves its purpose well. If you are looking for a reliable and easy-to-use spider killer that can also handle other common household pests, the Spectracide Bug Stop Home Barrier is a solid option.